Unix Timestamp: -11550729600
Monday, December 22. 1603, 12:00:00 AM UTC

The Accademia dei Lincei, the oldest scientific academy in the world, is founded in Rome by Federico Cesi.

Ottoman Dynasty: Sultan Mehmed III of the Ottoman Empire dies and is succeeded by his son Ahmed I.

The earliest of eight companies that would eventually merge to form the Kikkoman Corporation, the ubiquitous producers of soy sauce, is founded in Japan.

Johann Bayer publishes the star atlas "Uranometria", the first to cover the entire celestial sphere.

French Huguenot Pierre de Gua is granted royal permission to settle in North America, founding the colony of Acadia.

Russian famine of 1601–1603.

A rebellion breaks out in Transylvania.

Yaqob is deposed as Emperor of Ethiopia by Za Sellase, who appoints his cousin Za Dengel to replace him.