Galileo Galilei becomes the first astronomer to observe the planet Neptune when in conjunction with Jupiter, yet he mistakenly catalogues it as a fixed star because of its extremely slow motion along the ecliptic. Neptune is not truly discovered until 1846, about 234 years after Galileo first sights it with his telescope.
Jamestown: John Rolfe exports first crop of improved tobacco (seeds from Trinidad).
Thomas Shelton's English translation of the first half of "Don Quixote" is published. It is the first translation of the Spanish novel into any language.